THE EFFECT OF 2: 2-DIPHENYL-4-N-HEXAMETHYLENIMINO-BUTYRAM IDE METHIODIDE ON EXPERIMENTAL CHRONIC ULCER IN GLANDULAR STOMACH OF RATS

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Abstract

2: 2-Diphenyl-4-N-hexamethylenimino-butyramide methiodide (R-661) is one of the series of substituted diphenylpropyl-amines synthesized by Janssen et al. and is a typical quaternary atropine-like substance (1-9). It has anticholinergic activity, namely, parasympatholytic activity.<BR> Additionally, Janssen et al. reported that this compound showed the excellent gastrointestinal absorption and inhibited the formation of experimental gastric ulcer in rats (9). In the present experiments, an attempt was made histo-pharmacologically to evaluate the curative effect of R-661 on experimental ulcers in glandular stomachs of rats.

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