Effect of Maxacalcitol on Psoriasis Vulgaris-A Comparative Study of Maxacalcitol Ointment and High-concentration Tacalcitol Ointment-

KATOH Norito, KISHIMOTO Saburo

doi:10.2336/nishinihonhifu.68.299

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Other Title

尋常性乾癬に対するマキサカルシトール軟膏の効果‐マキサカルシトール軟膏と高濃度タカルシトール軟膏との左右比較試験‐
治療尋常性乾癬に対するマキサカルシトール軟膏の効果--マキサカルシトール軟膏と高濃度タカルシトール軟膏との左右比較試験
チリョウジンジョウセイカンセンニタイスルマキサカルシトールナンコウノコウカマキサカルシトールナンコウトコウノウドタカルシトールナンコウトノサユウヒカクシケン
—A Comparative Study of Maxacalcitol Ointment and High-concentration Tacalcitol Ointment—
—マキサカルシトール軟膏と高濃度タカルシトール軟膏との左右比較試験—

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Description

In 18 patients with psoriasis vulgaris, a bilateral-paired comparison study was conducted to evaluate the efficacy of maxacalcitol ointment 25μg/g (Oxarol^® Ointment) and tacalcitol ointment 20μg/g (Bonalfa^® High Ointment). As a rule, maxacalcitol ointment 25μg/g was applied once daily on weekdays and twice on each Saturday and Sunday, and tacalcitol ointment 20μg/g was applied once daily on each day during the study period. The ointments were applied for a period of 8 weeks to different sides of the body in a symmetrical manner. The percentage of patients with a moderate or superior alleviation at the time of final evaluation was 55.6% and 33.3% on the side treated with maxacalcitol ointment 25μg/g and tacalcitol ointment 20μg/g, respectively. Thus, both ointments exerted high efficacy. When overall improvement was compared between the two sides treated with different ointments, the outcome was better on the maxacalcitol-treated side in 33.3% of patients and on the tacalcitol-treated side in 11.1% of patients. These results suggest that topical treatment with maxacalcitol ointment 25μg/g (once daily on weekdays and twice on Saturdays and Sundays) is a useful treatment of psoriasis.

Journal

The Nishinihon Journal of Dermatology

The Nishinihon Journal of Dermatology 68 (3), 299-304, 2006

Western Division of Japanese Dermatological Association

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