A case of primary apocrine carcinoma with neuroendocrine differentiation occurring on the right parasternal region

DOI 8 References
  • IIJIMA Shigeruko
    Departments of Dermatology, Mito Saiseikai General Hospital
  • KANZAKI Mirei
    Departments of Dermatology, Mito Saiseikai General Hospital
  • MAKABE Kaoru
    Departments of Dermatology, Mito Saiseikai General Hospital
  • NAGAKURA Shigenori
    Surgery, Mito Saiseikai General Hospital
  • SUGANO Masato
    Department of Pathology, University of Tsukuba/Tsukuba Human Tissue Diagnostic Center
  • SAKATA Akiko
    Department of Pathology, University of Tsukuba/Tsukuba Human Tissue Diagnostic Center
  • NOGUCHI Masayuki
    Department of Pathology, University of Tsukuba/Tsukuba Human Tissue Diagnostic Center

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Other Title
  • 右傍胸骨部に生じた神経内分泌分化を示す皮膚原発アポクリン腺癌の1例

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Description

An 80-year-old Japanese man presented with a 10-year history of a slowly growing solitary tumor on his right parasternal region. A dermatological examination revealed a reddish erosive tumor, 20×19×5 mm in size, with oozing. No regional lymph node metastasis or other distant metastasis was detected. Under the clinical impression of sweat gland malignancy or amelanotic melanoma, the tumor was resected with a wide margin, and grafting was performed. Histopathological examination showed an asymmetric and elevated tumor with the main lesion located in the dermis. The tumor cells were arranged in a solid-nesting, trabecular, or ribbon-like appearance, which had comparatively regular oval nuclei and eosinophilic cytoplasm. Decapitation secretion was seen in part. Immunohistochemically, the tumor cells were positive for CAM5.2, EMA, gross cystic disease fluid protein-15, cytokeratin (CK)7, synaptophysin, chromogranin A, CD56, estrogen receptor, and progesterone receptor, and negative for CK20 and HER2. Further examination ruled out the existence of breast carcinoma. The patient was finally diagnosed with primary apocrine carcinoma with neuroendocrine differentiation. Sentinel node biopsy was not performed in accordance with the patient's wishes, and he took an anti-estrogen agent, tamoxifen, at 20 mg/day, after the diagnosis was made. No recurrence or metastasis of the tumor has been noted for 1 year and 8 months.[Skin Cancer (Japan) 2014 ; 29 : 165-170]

Journal

  • Skin Cancer

    Skin Cancer 29 (2), 165-170, 2015

    The Japanese Skin Cancer Society

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