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Expression of endothelial markers in angiosarcomas

  • ISHII Yoshiyuki
    <i>Department of Dermatology, Graduate School of Comprehensive Human Sciences, University of Tsukuba</i>
  • FUJISAWA Yasuhiro
    <i>Department of Dermatology, Graduate School of Comprehensive Human Sciences, University of Tsukuba</i>
  • NAKAMURA Yasuhiro
    <i>Department of Dermatology, Graduate School of Comprehensive Human Sciences, University of Tsukuba</i>
  • FURUTA Junichi
    <i>Department of Dermatology, Graduate School of Comprehensive Human Sciences, University of Tsukuba</i>
  • ICHIKAWA Eiko
    <i>Department of Dermatology, Graduate School of Comprehensive Human Sciences, University of Tsukuba</i>
  • KAWACHI Yasuhiro
    <i>Department of Dermatology, Graduate School of Comprehensive Human Sciences, University of Tsukuba</i>
  • OTSUKA Fujio
    <i>Department of Dermatology, Graduate School of Comprehensive Human Sciences, University of Tsukuba</i>

Bibliographic Information

Other Title
  • 頭部血管肉腫における内皮マーカー発現の検討

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Abstract

Angiosarcoma is a malignant tumor that commonly occurs on the head of the elderly. It seems that angiosarcomas are derived from endothelial cells in the vascular and/or lymphatic vessels. We examined the expression of endothelial markers CD31, CD34 and D2-40, using the immunohistochemistry for 11 cases of angiosarcomas. As a result, CD31 was positive in all cases. CD34 was positive in 7 cases. D2-40 was positive in 10 cases. CD31 was a specific vascular endothelial marker. D2-40 was a specific lymphatic endothelial marker. Ten cases of 11 angiosarcomas showed mixed expression of both vascular and lymphatic endothelial phenotypes. Thus, it suggested that the majority of angiosarcomas in our cases differentiate vascular and lymphatic endothelia.[Skin Cancer (Japan) 2009 ; 24 : 96-98]

Journal

  • Skin Cancer

    Skin Cancer 24 (1), 96-98, 2009

    The Japanese Skin Cancer Society

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