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- Nishimura Takayo
- 1st Department of Obstetrics and Gynecology, School of Medicine, Toho University
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- Sasabe Yutaka
- 1st Department of Obstetrics and Gynecology, School of Medicine, Toho University
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- Shibui Yukihiro
- 1st Department of Obstetrics and Gynecology, School of Medicine, Toho University
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- Ito Kanako
- 1st Department of Obstetrics and Gynecology, School of Medicine, Toho University
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- Katagiri Yukiko
- 1st Department of Obstetrics and Gynecology, School of Medicine, Toho University
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- Masaki Kazuo
- 1st Department of Obstetrics and Gynecology, School of Medicine, Toho University
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- Abe Yuji
- 1st Department of Obstetrics and Gynecology, School of Medicine, Toho University
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- Kubo Harumi
- 1st Department of Obstetrics and Gynecology, School of Medicine, Toho University
この論文をさがす
抄録
Preimplantation genetic diagnosis (PGD) is the technology used to avoid inheritance of genetic disease by selecting unaffected embryos. Furthermore PGD has made genetic screening of embryos possible. The limited number of cells available for genetic tests has been a serious problem with PGD. The first solution was the application of molecular technologies such as PCR, FISH and cell recycling. The next solution was the visualization of metaphase plates and application of advanced FISH technologies. The ideal solution was in vitro culture of blastomeres to increase the number of cells because it would be easy to reexamine them to assure the accuracy of genetic test results and obtain additional genetic information. The culture system for ES cells was applied to culturing mouse isolated blastomeres because it met two requirements: rapid proliferation and maintenance of the normal karyotype during culture. Our trial with mouse embryos successfully demonstrated these two requirements.
収録刊行物
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- 日本哺乳動物卵子学会誌
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日本哺乳動物卵子学会誌 19 (1), 1-5, 2002
日本卵子学会
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詳細情報 詳細情報について
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- CRID
- 1390282679316175616
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- NII論文ID
- 130004436647
- 10012144312
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- NII書誌ID
- AN10548943
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- ISSN
- 13475878
- 13417738
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- NDL書誌ID
- 6147319
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可