ジンコンを用いての溶媒抽出によるマレイン酸クロルフェニラミンの比色定量法

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タイトル別名
  • Spectrophotometric determination of chlorpheniramine maleate by solvent extraction with zincon
  • ジンコン オ モチイテ ノ ヨウバイ チュウシュツ ニヨル マレインサン クロ

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説明

A spectrophotometric method for the determination of chlorpheniramine maleate (MCP) by solvent extraction with zincon has been established. MCP is extracted as a 1 : 1 ion association complex with zincon in the organic phase, and determined by measuring absorbance of the extract at 530 nm. The absorbance of the extract showed to be linear over the concentration range of (1.0×10-51.0×10-4) M MCP in aqueous solution. Assay method is as follows: One ml of a sample solution containing (1.05.0)×10-4 M MCP is taken in a test tube and 5 ml of acetate (0.1 M) buffer (pH 4.6), 1 ml of zincon solution (1.0×10-3 M) and 3 ml of water are added. This solution is shaken with 5 ml of dichloromethane for 3 min. The extract is filtered through a dry filter paper to remove water. The absorbance is measured at 530 nm against either a reagent blank or water. The method proposed has high sensitivity and is applicable to the determination of MCP in drug preparations.

収録刊行物

  • 分析化学

    分析化学 27 (11), 707-711, 1978

    公益社団法人 日本分析化学会

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