A case of pulmonary diffuse large B-cell lymphoma presenting as a small solitary nodule

DOI 14 References
  • Motoishi Makoto
    Department of Thoracic Surgery, National Hospital Organization Kyoto Medical Center
  • Okamoto Keigo
    Department of Thoracic Surgery, National Hospital Organization Kyoto Medical Center
  • Kaku Ryosuke
    Department of Thoracic Surgery, National Hospital Organization Kyoto Medical Center
  • Sawai Satoru
    Department of Thoracic Surgery, National Hospital Organization Kyoto Medical Center

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  • 孤立性小結節影を呈した肺原発diffuse large B-cell lymphomaの1例

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A 70-year-old man with a history of COPD received chest CT. A small nodule of 7 mm in diameter was detected in segment 1 of the right lung. Retrospectively, the lesion was detectable about one year ago, and had slightly enlarged. Chest and abdominal CT did not show other obvious tumor lesions. PET-CT revealed no abnormal accumulation, including in the right lung nodule. Thoracoscopic partial resection, including the lesion, was performed for diagnosis and treatment. Microscopic examination showed the diffuse proliferation of large atypical lymphoid cells with rough chromatin and prominent nucleoli, and small lymphocytic cells. Immunohistochemically, the tumor cells stained positive for CD20 and CD79a, and high-level Ki67 expression was observed. The lesion was diagnosed as diffuse large B-cell lymphoma (DLBCL). PET-CT taken 5 months after the operation revealed no abnormal findings. The final diagnosis was pulmonary DLBCL presenting as a small solitary nodule.

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