Preparation of Tetrafluoroisophthalonitrile and Its Nucleophilic Substitution at 4-Position

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  • ハロゲン交換によるテトラフルオロイソフタロニトリルの合成とその求核置換反応
  • ハロゲン コウカン ニ ヨル テトラフルオロ イソフタロニトリル ノ ゴウセイ

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Abstract

Tetrachloroisophthalonitrile was fluorinated into tetrafluoroisophthalonitrile with spray-dried potassium fluoride and sulfolane. Under the optimum conditions, i. e., for 5 h at 290°, the yield of tetrafluoroisophthalonitrile was ca.80%.<BR>This polyfluorinated isophthalonitrile reacted with such nucleophiles as alcohols, phenols, and amines into the corresponding 4-substituted 2, 5, 6-trifluoroisophthalonitriles in excellent yields.<BR>As a result of biocidal evaluation, it was found that these compounds possessed strong antimicrobial activities.

Journal

  • NIPPON KAGAKU KAISHI

    NIPPON KAGAKU KAISHI 1985 (11), 2155-2160, 1985-11-10

    The Chemical Society of Japan

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