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Time Courses in the Blood and Antivasospasm Effects of Fasudil Hydrochloride and the Metabolite in Patients with Subarachnoid Hemorrhage
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- Kazuki Shuji
- Department of Neurosurgery, Brain and Spine Surgical Center, Shiroyama Hospital
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- Tanabe Hideki
- Department of Neurosurgery, Brain and Spine Surgical Center, Shiroyama Hospital
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- Matsukawa Masanori
- Department of Neurosurgery, Brain and Spine Surgical Center, Shiroyama Hospital
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- Sumioka Shinya
- Department of Neurosurgery, Brain and Spine Surgical Center, Shiroyama Hospital
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- Isono Naohumi
- Department of Neurosurgery, Brain and Spine Surgical Center, Shiroyama Hospital
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- Yasuda Soichiro
- Department of Neurosurgery, Brain and Spine Surgical Center, Shiroyama Hospital
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- Miyamoto Takashi
- Department of Neurosurgery, Osaka Medical College
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- Ohta Tomio
- Department of Neurosurgery, Osaka Medical College
Bibliographic Information
- Other Title
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- クモ膜下出血患者における塩酸ファスジルおよび代謝産物M3の経時的血中濃度変化とその脳血管攣縮予防効果について
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Description
It has been reported that fasudil hydrochroride, which is an inhibitor of protein kinases such as myosine light chain kinase, has a vasodilating effect on cerebral arteries and a preventive effect for cerebral vasospasm after subarachnoid hemorrhage. However, its half life in blood is very short. Therefore, it is not clear whether it maintains an effective blood concentration in clinical cases. On the other hand, hydroxy fasudil(M3), which is metabolite of fasudil hydrochloride, has a brain protective effect and its half life in blood is very long. The authors investigated the time course of the blood concentration of fasudil hydrochloride and hydroxy fasudil, and evaluated their preventive effect for cerebral vasospasm.
Journal
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- Japanese Journal of Neurosurgery
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Japanese Journal of Neurosurgery 9 (3), 146-151, 2000
The Japanese Congress of Neurological Surgeons
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Details 詳細情報について
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- CRID
- 1390282679385687168
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- NII Article ID
- 110003813427
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- NII Book ID
- AN10380506
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- ISSN
- 21873100
- 0917950X
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed