Time Courses in the Blood and Antivasospasm Effects of Fasudil Hydrochloride and the Metabolite in Patients with Subarachnoid Hemorrhage

DOI Web Site 9 References
  • Kazuki Shuji
    Department of Neurosurgery, Brain and Spine Surgical Center, Shiroyama Hospital
  • Tanabe Hideki
    Department of Neurosurgery, Brain and Spine Surgical Center, Shiroyama Hospital
  • Matsukawa Masanori
    Department of Neurosurgery, Brain and Spine Surgical Center, Shiroyama Hospital
  • Sumioka Shinya
    Department of Neurosurgery, Brain and Spine Surgical Center, Shiroyama Hospital
  • Isono Naohumi
    Department of Neurosurgery, Brain and Spine Surgical Center, Shiroyama Hospital
  • Yasuda Soichiro
    Department of Neurosurgery, Brain and Spine Surgical Center, Shiroyama Hospital
  • Miyamoto Takashi
    Department of Neurosurgery, Osaka Medical College
  • Ohta Tomio
    Department of Neurosurgery, Osaka Medical College

Bibliographic Information

Other Title
  • クモ膜下出血患者における塩酸ファスジルおよび代謝産物M3の経時的血中濃度変化とその脳血管攣縮予防効果について

Search this article

Description

It has been reported that fasudil hydrochroride, which is an inhibitor of protein kinases such as myosine light chain kinase, has a vasodilating effect on cerebral arteries and a preventive effect for cerebral vasospasm after subarachnoid hemorrhage. However, its half life in blood is very short. Therefore, it is not clear whether it maintains an effective blood concentration in clinical cases. On the other hand, hydroxy fasudil(M3), which is metabolite of fasudil hydrochloride, has a brain protective effect and its half life in blood is very long. The authors investigated the time course of the blood concentration of fasudil hydrochloride and hydroxy fasudil, and evaluated their preventive effect for cerebral vasospasm.

Journal

References(9)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top