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Hemodynamics of Bleb Formation in Cerebral Aneurysms
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- Miura Yoichi
- Department of Neurosurgery, Mie University Graduate School of Medicine
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- Ishida Fujimaro
- Department of Neurosurgery, Mie Chuo Medical Center, National Hospital Organization
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- Umeda Yasuyuki
- Department of Neurosurgery, Mie University Graduate School of Medicine
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- Tanaka Katsuhiro
- Department of Neurosurgery, Kuwana City Hospital
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- Fukazawa Keiji
- Department of Neurosurgery, Mie Chuo Medical Center, National Hospital Organization
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- Suzuki Hidenori
- Department of Neurosurgery, Mie University Graduate School of Medicine
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- Matsushima Satoshi
- Department of Neurosurgery, Mie University Graduate School of Medicine
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- Shimosaka Shinichi
- Department of Neurosurgery, Mie Chuo Medical Center, National Hospital Organization
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- Taki Waro
- Department of Neurosurgery, Mie University Graduate School of Medicine
Bibliographic Information
- Other Title
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- CFD解析によるブレブ発生と増大メカニズムの検討
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Description
Background and purposes : In clipping surgery for aneurysmal subarachnoid hemorrhage, the aneurysmal bleb is often conformed as the rupture point. Moreover, aneurysmal blebs have been identified as a factor for increased risk of rupture. We investigate possible associations between the hemodynamics and the formation of blebs in cerebral aneurysms. Methods : A patient with a growing aneurysmal bleb was selected for this study. Computational fluid dynamics simulations were performed under pulsatile flow conditions for the bleb model and the bleb cut model which was constructed by virtually removing the bleb. Results : Normalized wall shear stress (NWSS), gradient oscillatory number (GON), oscillatory shear index (OSI) and static pressure (SP) in the bleb formation area were higher than those in the aneurysmal dome. The aneurysm formation indicator (AFI) in the bleb formation area was similar to AFI in the aneurysmal dome. Wall shear stress gradient (WSSG) in the bleb formation area was smaller than WSSG in the aneurysmal dome. The specific parameter for bleb formation area was SP. Bleb growing states lead to reduction of OSI, NWSS, OSI and GON. In visualizations of flow structures, a high-flow jet impacted the bleb formation area. Conclusions : These results suggest that aneurysmal blebs are formed by damage caused by static pressure and the aneurysmal wall inflow jet based on the endothelial dysfunction.
Journal
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- Japanese Journal of Neurosurgery
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Japanese Journal of Neurosurgery 21 (5), 413-419, 2012
The Japanese Congress of Neurological Surgeons
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Details 詳細情報について
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- CRID
- 1390282679386317056
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- NII Article ID
- 110009445700
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- NII Book ID
- AN10380506
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- ISSN
- 21873100
- 0917950X
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
- OpenAIRE
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- Abstract License Flag
- Disallowed