ミノサイクリンの局所的応用による歯周炎治療法　　ＬＳ‐００７による治療方法の臨床的検討

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  • Periodontal therapy by local delivery of minocycline. Clinical study of periodontal therapy by LS-007.
  • Clinical Study of Periodontal Therapy by LS-007
  • LS-007による治療方法の臨床的検討

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Our previous studies have been performed to establish methods for local delivery of Minocycline hydrochloride (MINO: Lederle Japan, LTD, Tokyo) in a therapy for periodontal disease.<BR>This study was done clinically to evaluate the effectiveness, safety, and usefulness of a LS-007 medicine containing 2 percent titers of MINO. Forty five periodontitis patients (119 teeth) with periodontal pockets (≥4mm) participated in this study. The experimental systems were evaluated by comparing microbiological and clinical effectiveness of LS-007, placebo, and Minocycline tablet (Lederle Japan, LTD).<BR>The results were as follows, <BR>1. The effectiveness of LS-007 was examined in two delivery system ; in one system the medicine was redelivered after one week, and in the other system after two weeks. Both systems revealed similar effectiveness until after two weeks from the last delivery.<BR>2. When LS-007 was delivered once in a week for 4 successive weeks, LS-007 demonstrated its effectiveness until after 4 weeks from the last delivery.<BR>3. A pretreatment with scaling prior to the application of LS-007 raised the effectiveness of LS-007.<BR>4. The systemic delivery of Minomycine tablet demonstrated microbiologically and clinically similar effect to the local delivery of LS-007. In the systemic delivery, however, there was a subject who suffered harmful side effect of the medicine.<BR>From these results, we concluded the local delivery of LS-007 was clinically effective, safe, and useful as a therapy for periodontal disease.

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