Vacuolar Change in the Thyroid Follicular Cells in BrlHan: WIST@Jcl(GALAS) Rats.

Shimoi Akihito, Kuwayama Chitose, Miyauchi Makoto, Kakinuma Chihaya, Kamiya Masatsugu, Harada Tsuyoshi, Ogihara Takuo, Kurokawa Misao, Mizuguchi Kiyoshi

doi:10.1293/tox.14.253

Search this article

Description

Huge vacuoles in the follicular epithelial cells distributing diffusely in the thyroid gland were seen in 2 out of 36 males and 8 out of 82 females of BrlHan: WIST@Jcl (GALAS) rats examined histopathologically. The vacuoles showed negative reactivity by periodic acid-Schiff reaction and thyroglobulin-immunohistochemistry. Corresponding to the vacuoles, remarkable dilatation of rough endoplasmic reticulum was seen in electron microscopic observation. The animals in which the thyroid lesion was found had shown no abnormalities in behavior, body weight, food consumption, or hematological and biochemical examinations. Plasma concentrations of thyroid-stimulating hormone (TSH) and thyroid hormones (T3 and T4) were not different from those of normal rats. From these results, thyroid functions seemed to be kept normal in spite of the severe morphological change. Based on the character and incidence of the thyroid lesion, it was presumed to be related with a certain genetic factor of one or several parents of breeding rats rather than food contamination or infection.

Journal

Journal of Toxicologic Pathology

Journal of Toxicologic Pathology 14 (3), 253-257, 2001

JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY

Keywords

Details 詳細情報について

CRID: 1390282679392368896

NII Article ID: 10030907589

NII Book ID: AA12022786

DOI: 10.1293/tox.14.253

ISSN: 1881915X; 09149198

Web Site: http://www.jstage.jst.go.jp/article/tox/14/3/14_3_253/_pdf; https://search.jamas.or.jp/link/ui/2002078863

Text Lang: en

Data Source

JaLC
Crossref
CiNii Articles
OpenAIRE

Abstract License Flag: Disallowed

Export

Report a problem