書誌事項
- タイトル別名
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- Potential Application of Molecular Techniques for the Evaluation of Endocrine-disrupting Chemicals in Leachate from Waste Landfill
- ナイブンピ カクラン サヨウ オ ケンシュツ スル イデンシ レベル ノ バイオアッセイ
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説明
We critically review the current and potential application of molecular techniques in assessing the adverse biological reproductive effects of endocrine-disrupting chemicals (EDCs) in leachate from waste landfills. Various in vitro screening assays have been developed to evaluate EDCs that may bind to sex hormone receptors. Screening assays such as the receptor-binding assay to check the direct binding ability of a chemical with the receptor and the use of cultured cells such as MCF-7 cells and yeast cells in which the receptor gene is inserted are frequently used. As for in vivo assays, plasma and/or hepatic vitellogenin induction assays to determine estrogenic activity have been used in fish and amphibians. In addition, molecular techniques, such as real-time polymerase chain reaction (PCR) and cDNA-microarray, are considered to be useful tools for risk assessment of animals and humans exposed to leachate from waste landfills. This review provides a link between traditional single-gene biomarker studies and the emerging field of eco-toxicogenomics, demonstrating the utility of microarray studies on environmentally sampled, non-model organisms.
収録刊行物
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- 廃棄物学会誌
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廃棄物学会誌 15 (5), 240-246, 2004
一般社団法人 廃棄物資源循環学会
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詳細情報 詳細情報について
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- CRID
- 1390282679392500608
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- NII論文ID
- 10013394466
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- NII書誌ID
- AN10414674
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- ISSN
- 18838960
- 09170855
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- NDL書誌ID
- 7127917
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可
