Danshen Inhibits Oxysterol-induced Endothelial Cell Apoptosis In Vivo
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- Nakazawa Toru
- National Cardiovascular Center Research Institute, Osaka, Japan. Tokyo Medical and Dental University Graduate School, Tokyo, Japan. First Institute of New Drug Discovery, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan.
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- Xui Ning
- National Cardiovascular Center Research Institute, Osaka, Japan.
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- Hesong Zeng
- National Cardiovascular Center Research Institute, Osaka, Japan.
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- Kinoshita Mikio
- National Cardiovascular Center Research Institute, Osaka, Japan.
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- Chiba Tsuyoshi
- National Cardiovascular Center Research Institute, Osaka, Japan. Tokyo Medical and Dental University Graduate School, Tokyo, Japan.
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- Kaneko Eiji
- Tokyo Medical and Dental University Graduate School, Tokyo, Japan.
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- Yui Katsumasa
- Tokyo Medical and Dental University Graduate School, Tokyo, Japan.
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- Shimokado Kentaro
- National Cardiovascular Center Research Institute, Osaka, Japan. Tokyo Medical and Dental University Graduate School, Tokyo, Japan.
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Abstract
Oxysterols induce apoptosis in vascular endothelial cells in vitro, but it is not clear whether they do so in vivo. We intravenously injected an oxysterol, cholestan-3β, 5α, 6β-triol, into rats and quantitatively analyzed endothelial cell apoptosis in the aorta. Oxysterol significantly promoted apoptosis in a time- and dose-dependent fashion. The apoptosis had increased 4.5-fold 6 hrs after injection, and returned to the background level at 48 hrs. An extract of the Chinese herb Danshen as well as probucol abolished triol-induced endothelial cell apoptosis in vitro and in vivo. Since apoptotic cells are quickly cleared, oxysterol-induced apoptosis could significantly affect endothelial integrity over a long period of time. Radical scavengers may be useful for the prevention of endothelial damage.
Journal
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- Journal of Atherosclerosis and Thrombosis
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Journal of Atherosclerosis and Thrombosis 12 (3), 132-137, 2005
Japan Atherosclerosis Society
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Details
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- CRID
- 1390282679407998592
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- NII Article ID
- 130004444133
- 10018365725
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- NII Book ID
- AA11018976
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- ISSN
- 18803873
- 13403478
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- PubMed
- 16020912
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed