Depot-specific expression of lipolytic genes in human adipose tissues—association among CES1 expression, triglyceride lipase activity and adiposity
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- Nagashima Shuichi
- Division of Endocrinology and Metabolism, Diabetes Center, Department of Medicine, Jichi Medical University.
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- Yagyu Hiroaki
- Division of Endocrinology and Metabolism, Diabetes Center, Department of Medicine, Jichi Medical University.
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- Takahashi Nirei
- Division of Endocrinology and Metabolism, Diabetes Center, Department of Medicine, Jichi Medical University.
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- Kurashina Tomoyuki
- Division of Endocrinology and Metabolism, Diabetes Center, Department of Medicine, Jichi Medical University.
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- Takahashi Manabu
- Division of Endocrinology and Metabolism, Diabetes Center, Department of Medicine, Jichi Medical University.
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- Tsuchita Takeshi
- Division of Endocrinology and Metabolism, Diabetes Center, Department of Medicine, Jichi Medical University.
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- Tazoe Fumiko
- Division of Endocrinology and Metabolism, Diabetes Center, Department of Medicine, Jichi Medical University.
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- Wang Xiao Li
- Division of Endocrinology and Metabolism, Diabetes Center, Department of Medicine, Jichi Medical University.
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- Bayasgalan Tumenbayar
- Division of Endocrinology and Metabolism, Diabetes Center, Department of Medicine, Jichi Medical University.
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- Sato Naoko
- Division of Endocrinology and Metabolism, Diabetes Center, Department of Medicine, Jichi Medical University.
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- Okada Kenta
- Division of Endocrinology and Metabolism, Diabetes Center, Department of Medicine, Jichi Medical University.
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- Nagasaka Shoichiro
- Division of Endocrinology and Metabolism, Diabetes Center, Department of Medicine, Jichi Medical University.
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- Gotoh Takaya
- Division of Human Genetics, Center for Community Medicine, Jichi Medical University.
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- Kojima Masayuki
- Department of Surgery, Jichi Medical University.
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- Hyodo Masanobu
- Department of Surgery, Jichi Medical University.
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- Horie Hisanaga
- Department of Surgery, Jichi Medical University.
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- Hosoya Yoshinori
- Department of Surgery, Jichi Medical University.
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- Okada Masaki
- Department of Surgery, Jichi Medical University.
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- Yasuda Yoshikazu
- Department of Surgery, Jichi Medical University.
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- Fujiwara Hiroyuki
- Department of Obstetrics and Gynecology, Jichi Medical University.
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- Ohwada Michitaka
- Department of Obstetrics and Gynecology, Jichi Medical University.
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- Iwamoto Sadahiko
- Division of Human Genetics, Center for Community Medicine, Jichi Medical University.
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- Suzuki Mitsuaki
- Department of Obstetrics and Gynecology, Jichi Medical University.
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- Nagai Hideo
- Department of Surgery, Jichi Medical University. Department of Surgery, Ibaraki Prefectural Central Hospital.
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- Ishibashi Shun
- Division of Endocrinology and Metabolism, Diabetes Center, Department of Medicine, Jichi Medical University.
書誌事項
- タイトル別名
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- Depot-Specific Expression of Lipolytic Genes in Human Adipose Tissues
- Depot-specific expression of lipolytic genes in human adipose tissues--association among CES1 expression, triglyceride lipase activity and adiposity
- —Association Among <i>CES1</i> Expression, Triglyceride Lipase Activity and Adiposity
この論文をさがす
説明
Aim: Adipocyte lipolysis is mediated by a family of triglyceride (TG) lipases consisting of hormone-sensitive lipase (LIPE), adipose triglyceride lipase (PNPLA2) and carboxylesterase 1 (CES1); however, little is known about the relationship between the expression of each gene in different depots and TG lipase activity or obesity.<BR>Method: We measured both mRNA expression levels of the lipolytic enzymes (LIPE, PNPLA2 and CES1) and TG lipase activities of biopsy samples obtained from subcutaneous, omental and mesenteric adipose tissues of 34 patients who underwent abdominal surgery. The results were correlated with clinical parameters: adiposity measures, parameters for insulin resistance and plasma lipid levels.<BR>Results: PNPLA2 mRNA levels were slightly higher in omental fat than subcutaneous fat. Cytosolic TG lipase activities were positively correlated with the mRNA levels of CES1 in subcutaneous fat and mesenteric fat, while they were correlated with those of PNPLA2 in omental fat. The mRNA levels of LIPE were negatively correlated with various measures of adiposity in subcutaneous fat. The mRNA levels of CES1 were positively correlated with various measures of adiposity, particularly those estimated by CT in the three depots; they were also positively correlated with plasma LDL-cholesterol levels in omental fat. In contrast, the mRNA levels of PNPLA2 were not significantly associated with adiposity.<BR>Conclusions: The positive correlations of the expression of CES1 with cytosolic TG lipase activities as well as with adiposity suggest that CES1 is involved in lipolysis, thereby contributing to the development of obesity-associated phenotypes. On the other hand, the expression of LIPE is negatively correlated with adiposity. These distinct regulatory patterns of lipolytic genes may underlie the complex phenotypes associated with human obesity.
収録刊行物
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- Ｊｏｕｒｎａｌ ｏｆ Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ ａｎｄ Ｔｈｒｏｍｂｏｓｉｓ
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Ｊｏｕｒｎａｌ ｏｆ Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ ａｎｄ Ｔｈｒｏｍｂｏｓｉｓ 18 (3), 190-199, 2011
一般社団法人 日本動脈硬化学会
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詳細情報 詳細情報について
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- CRID
- 1390282679410094848
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- NII論文ID
- 130004444498
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- DOI
- 10.5551/jat.6478
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- ISSN
- 18803873
- 13403478
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- PubMed
- 21081832
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
- KAKEN
- OpenAIRE
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- 抄録ライセンスフラグ
- 使用不可