In Vitro Anti-Helicobacter pylori Activity of Chinese Chive (Allium tuberosum)

この論文をさがす

説明

The anti-Helicobacter pylori (H. pylori) activity of a water extract of Chinese chive (Allium tuberosum) (WCC) was investigated. On disk diffusion assay, WCC effectively inhibited the growth of all 21 strains tested, including isogenic mutants, showing inhibition diameters of 12 to 29 mm, irrespective of drug susceptibility and clinical manifestation. The minimum inhibitory concentration (MIC) of WCC was 2.45 mg dry weight/mL. Killing assay with multiples of MIC confirmed that WCC had bactericidal activity and that the inhibitory effects were dose dependent. In addition, to determine whether the inhibitory activity of WCC under severe stress conditions, such as heat and acidity, is altered, the stability of WCC was evaluated. The inhibitory activity of WCC exposed to acidic conditions (pH 1.0 to 6.4) was stable, while heat-treated WCC (100°C, 10 min) showed slightly decreased inhibition activity. On combination assay with antibiotics frequently used in clinical practice, WCC was found to be an innocuous agent for antibiotic activity. These results suggest that daily intake of WCC is able to prevent H. pylori colonization in the stomach, and that it could be applied as adjuvant therapy in H. pylori eradication.

収録刊行物

被引用文献 (3)*注記

もっと見る

参考文献 (73)*注記

もっと見る

関連プロジェクト

もっと見る

詳細情報 詳細情報について

  • CRID
    1390282679434500096
  • NII論文ID
    10030897352
  • NII書誌ID
    AA11320122
  • DOI
    10.3136/fstr.17.505
  • ISSN
    18813984
    13446606
  • 本文言語コード
    en
  • 資料種別
    journal article
  • データソース種別
    • JaLC
    • Crossref
    • CiNii Articles
    • KAKEN
    • OpenAIRE
  • 抄録ライセンスフラグ
    使用不可

問題の指摘

ページトップへ