Determination of Oxygen Ingress Through Syringe Packages by Using Laser Headspace Analysis

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  • ヘッドスペース分析を用いたシリンジパッケージを通じた酸素侵入の判定

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  Syringes and cartridges need to be a barrier to microbial ingress and in some cases (e.g. oxygen sensitive formulations) oxygen ingress. Container Closure Integrity (CCI) is the main measure of a packages ability to maintain stability and sterility over the intended shelf life.<br>   We develop laser headspace analysis for assessing oxygen ingress rates into two types of syringe packages. We measure oxygen ingress to a Luer Tip and Staked Needle syringe package. The syringe packages were prepared in a way that allowed isolated study of different parts of each syringe so that oxygen ingress rates could be determined for each part of the syringe.<br>

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