Introduction to Biostatistics in Clinical Research

DOI 2 References
  • Sato Yasunori
    Department of Global Clinical Research, Graduate School of Medicine, Chiba University
  • Gosho Masahiko
    Department of Clinical Trial and Clinical Epidemiology, University of Tsukuba Faculty of Medicine

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  • 臨床研究における生物統計学の基礎

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Evidence based medicine (EBM) has been described as a new approach to teaching and practicing clinical medicine. Statistical methods are useful for the correct interpretation of the results in proof of the evidence; therefore biostatistics is an important element of EBM. Furthermore, maintaining and fostering good communication between medical doctors and biostatisticians will lead to good relationships and success. In this article, we highlight several important aspects related to the design and statistical analysis for clinical research. First, we focus on a special type of bias called 'confounding'. Next we present concerns regarding misuse of statistical software. Finally, we review what statistical methods are frequently being used in clinical research, then present recent trends and perspectives of statistical methods.

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