RSV Infection and Asthma

DOI 40 References
  • Hashimoto Koichi
    Department of Pediatrics, School of Medicine, Fukushima Medical University
  • Kawasaki Yukihiko
    Department of Pediatrics, School of Medicine, Fukushima Medical University
  • Hosoya Mitsuaki
    Department of Pediatrics, School of Medicine, Fukushima Medical University

Bibliographic Information

Other Title
  • ＲＳウイルス感染と喘息発症―ＲＳＶ感染とＳＯＣＳ発現について―
  • ―RSV感染とSOCS発現について―

Search this article

Description

Human respiratory syncytial virus (RSV), a major respiratory viral pathogen, is an enveloped and negative-strand RNA paramyxovirus. Epidemiologic studies show that lower respiratory tract infections caused by RSV is risk factor for both recurrent wheezing and childhood asthma. The pathogenesis of wheezing diseases post-viral infection would be due to (host) Gene-Virus Interaction. The suppressor of cytokines signaling (SOCS) gene family utilizes a feedback loop to inhibit cytokine responses and block the activation of the JAK/STAT signaling pathway. RSV infection up-regulated SOCS1, SOCS3, and CIS mRNA expression in human laryngeal carcinoma cell line, HEp-2 cell. The pathogenesis of wheezing diseases post-viral infection could be declared by the study of SOCS expression in structural cells, such as endothelial, epithelial, smooth muscle, nerve cells, and inflammatory cells within the lung.

Journal

References(40)*help

See more

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top