Review of Carcinogenicity of Titanium Dioxide

DOI
  • EMA Makoto
    National Institute of Advanced Industrial Science and Technology
  • KOBAYASHI Norihiro
    National Institute of Advanced Industrial Science and Technology
  • NAYA Masato
    National Institute of Advanced Industrial Science and Technology
  • HANAI Sosuke
    National Institute of Advanced Industrial Science and Technology
  • NAKANISHI Junko
    National Institute of Advanced Industrial Science and Technology

Bibliographic Information

Other Title
  • 二酸化チタンの発がん性評価

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Description

The present paper reviews the carcinogenicity study of titanium dioxide（TiO2），widely used in the production of paints paper and plastics, as food additives and colorants, and increasingly, as nanpoparticles in pharmaceutical and cosmetics products, based on data published in openly available scientific literature. Increased incidence of tumors was reported in rats after exposure to respirable, fine or ultrafine TiO2 by inhalation or intratracheal instillation. No increased incidence of tumors was noted in mice or hamster after exposure to TiO2 by inhalation or intratracheal instillation, or in rats or mice given TiO2 by intraperitoneal or subcutaneous injection or by feeding. This review indicates that the incidence of tumors was increased in rats after inhalation or intratracheal instillation of TiO2　at levels associated with particle overload and persistent inflammation.

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Details 詳細情報について

  • CRID
    1390282679462254080
  • NII Article ID
    130004542790
  • DOI
    10.11403/jset.13.15
  • ISSN
    18825958
    13440667
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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