Percutaneous Absorption of Amono Acids into Human Skin In Vitro.

DOI

Bibliographic Information

Other Title
  • Ｉｎ　ｖｉｔｒｏによるアミノ酸のヒト皮膚での経皮吸収挙動の解析

Description

Five amino acids (L-lysine hydrochloride, glycine, sodium L-glutamate L-proline, and L-threonine) were used in this study. Their percutaneous absorption from pH 7.4 aqueous solution (PBS buffered saline) were investigated on human cadaver skin. The effects of glycerin, sodium PCA etc. on the absorption of L-proline were also investigated. Amino acids did not penetrate into the reservoir within a few hours but the amounts of adsorbed amino acid in stratum corneum were increased when glycerin or sodium PCA was incorporrated. A negative correlation between flux and log P (n-octand/water) was observed when the amino acid penetration into the receiver solution reached steady state. These resulls suggest not only the possibility of micro channels for amino acid permeation into human skin but also the possibility of incorporating amino acids into skin surface to subserve skin function.

Journal

Details 詳細情報について

  • CRID
    1390282679476896128
  • NII Article ID
    130004188723
  • DOI
    10.5107/sccj.30.55
  • ISSN
    18844146
    03875253
  • Text Lang
    ja
  • Data Source
    • JaLC
    • Crossref
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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