Bactericidal Effects of Chitosan from Squid Pens on Oral Streptococci
Bibliographic Information
- Other Title
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- イカ軟甲キトサンのう蝕原性レンサ球菌に対する抗菌作用
- イカ ナンコウ キトサンノ ウショク ゲンセイ レンサキュウキン ニ タイスル
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Abstract
Bactericidal effects of various chitosan samples from squid pens (SP-chitosan) against the Streptococcus mutans group have been investigated. Antimicrobial action of 0.0005% (5μg/ml) SP-chitosan varied greatly depending on the molecular weight of chitosan as well as the species of oral streptococci. The SP-chitosan samples with molecular weights in the range 70-426 kDa had marked antibacterial activity on all the streptococci tested. S. mutans, S. sobrinus, and S. salivarius turned out to be especially sensitive to the SP-chitosan. The bactericidal effect of the 220 kDa SP-chitosan was observed even in a short incubation time (15 sec.) against S. mutans strain GS 5, and its ED50 was 0.00007% (0.7μg/ml). In addition, its antibacterial activity against the same bacteria was greater with increasing degree of deacetylation of SP-chitosan. These results suggest that the SP-chitosan having a high molecular weight and high degree of deacetylation would be useful as an anti-caries agent.
Journal
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- Nippon Nōgeikagaku Kaishi
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Nippon Nōgeikagaku Kaishi 70 (7), 787-792, 1996
Japan Society for Bioscience, Biotechnology, and Agrochemistry
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Details 詳細情報について
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- CRID
- 1390282679483714560
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- NII Article ID
- 110002791249
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- NII Book ID
- AN00196191
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- COI
- 1:CAS:528:DyaK28XktVSks7g%3D
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- ISSN
- 18836844
- 00021407
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- NDL BIB ID
- 3986955
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed