シスチンの酵素的生産工程における管理指標の探索

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  • A Criterion for the Optimization of the Process Producing L-Cystine on an Industrial Scale.
  • シスチン ノ コウソテキ セイサン コウテイ ニ オケル カンリ シヒョウ ノ タンサク

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説明

L-Cystein (CysH) is produced from DL-2-thiazolin-4-carboxylic acid (ATC) using enzymatic activity of Pseudomonas strains, and the oxidized to produce L-cystine (Cys). Criteria for the optimization of the process producing Cys were studied for the scaling up of this process.<br> The oxidation-reduction potential (ORP) was found to be useful to optimize the process. The ORP value of -450 mV was optimum to produce Cys at the highest yield of 83% (mol yield) from the 75mg/mL of ATC in a bench plant scale reactor.

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