書誌事項
- タイトル別名
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- Evaluation of Pharmaceutical Glidant with Atomic Force Microscope and Mechanism of Flowability Enhancement
説明
The effect of geometric surface structure of glidant on flowability of pharmaceutical fillers and the factors that determine the optimum amount of glidant added were investigated with AFM and IR spectroscopy. Several types of silica particles were used as a glidant in preparing the mixture of lactose and microcrystalline cellulose. The flowability of mixed powder was evaluated with Can's index. As a result, it was found that the flowability and the optimum mixing ratio depend on the geometric surface structure of glidant. AFM study showed that the porosity of silica particles plays an important role in determining flowability through the reduction in adhesion force. Furthermore, IR study suggested that the optimum mixing ratio is closely related to the surface coverage of filler with glidant. The optimum mixing ratio of porous silica is smaller than that of nonporous silica since the surface coating with porous silica is completed at a lower mixing ratio.
収録刊行物
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- 粉体工学会誌
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粉体工学会誌 41 (3), 169-176, 2004
一般社団法人 粉体工学会
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詳細情報 詳細情報について
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- CRID
- 1390282679489234176
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- NII論文ID
- 130003952628
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- COI
- 1:CAS:528:DC%2BD2cXivVaiurc%3D
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- ISSN
- 18837239
- 03866157
- http://id.crossref.org/issn/03866157
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
- OpenAIRE
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- 抄録ライセンスフラグ
- 使用不可
