免疫グロブリン大量静注療法が奏効したＢｉｃｋｅｒｓｔａｆｆ型脳幹脳炎の小児例

DOI PubMed 参考文献16件

書誌事項

タイトル別名
  • High-dose Intravenous Immunoglobulin Therapy in a Child Case of Bickerstaff's Brainstem Encephalitis
公開日
2003
資源種別
journal article
DOI
  • 10.11251/ojjscn1969.35.327
公開者
THE JAPANESE SOCIETY OF CHILD NEUROLOGY

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説明

We report an 11-year-old boy with Bickerstaff's brainstem encephalitis (BBE). He had gait disturbance, disturbed consciousness, and diplopia after upper respiratory tract infection. On admission, he showed multiple cranial nerve palsy, muscle weakness of arms, cerebeller ataxia and generalized areflexia. The cerebrospinal fluid on day 7 revealed albuminocytologic dissociation. IgG antibodies against GQ1b and GT 1 a were detected in the serum. Immunoglobulin was administered intravenously from day 11, and then his symptoms gradually diminished. When he was discharged on day 27, he had neither conscious disturbance nor limb weakness. There still were mild ophthalmoparesis and diminished deep tendon reflexes, but they disappeared by 10 months after the onset.<BR>Effective therapy for BBE has yet to be established. Our case had features of Guillain-Barre syndrome (GBS) and Miller Fisher syndrome, such as an acute monophasic course, limb weakness with areflexia, albuminocytologic dissociation in the cerebrospinal fluid, detection of serum anti-ganglioside antibodies and efficacy of intravenous immunoglobulin, indicating that BBE and GBS are closely related. Our case suggested that intravenous immunoglobulin therapy, an established treatment for GBS, should be considered in some patients with BBE.

収録刊行物

  • 脳と発達

    脳と発達 35 (4), 327-330, 2003

    THE JAPANESE SOCIETY OF CHILD NEUROLOGY

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