Discovery of synthetic methoxysubstituted - phenylbutyric acid derivatives as chemical chaperons

DOI PDF 被引用文献6件 参考文献16件
  • Mimori Seisuke
    Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chiba Institute of Science
  • Okuma Yasunobu
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Chiba Institute of Science
  • Kaneko Masayuki
    Medical Therapeutics and Molecular Therapeutics, Gifu Pharmaceutical University
  • Kawada Koichi
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Chiba Institute of Science
  • Nomura Yasuyuki
    Laboratory of Pharmacotherapeutics, Yokohama College of Pharmacy
  • Murakami Yasuoki
    Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chiba Institute of Science
  • Hamana Hiroshi
    Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chiba Institute of Science

書誌事項

タイトル別名
  • Discovery of Synthetic Methoxy-substituted 4-Phenylbutyric Acid Derivatives as Chemical Chaperones
公開日
2013
資源種別
journal article
DOI
  • 10.1246/cl.130419
公開者
公益社団法人 日本化学会

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説明

In this study, we evaluated the chemical chaperone activity of synthetic 4-phenylbutyric acid (4-PBA) derivatives. These derivatives have a methoxy group at the benzene ring and/or longer or shorter fatty acid portions. Several 4-PBA derivatives demonstrated higher antiaggregation activity than 4-PBA. Moreover, 4-(4-methoxyphenyl)butanoic acid (7b) showed protective effects against endoplasmic reticulum stress-induced neuronal cell death.

収録刊行物

  • Chemistry Letters

    Chemistry Letters 42 (9), 1051-1052, 2013

    公益社団法人 日本化学会

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