書誌事項
- タイトル別名
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- Role of Superoxide Production by Macrophages in the Inflammatory Reaction of the Lung Induced by Asbestos Inhalation.
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The present study was performed to clarify the role of active oxygen species produced by macrophages in acute lung injury induced by asbestos (chrysotile) inhalation. Using a sound-wave sifter, we separated chrysotile particles into two types, i.e., fibrous and granular ones, and measured the chemiluminescence (CL) velocity when each type was mixed in a macrophage suspension together with a chemiluminescent agent, lucigenin. The CL was inhibited by superoxide dismutase (SOD), indicating that superoxide is produced in this reaction. The CL intensity was enhanced in the case of fibrous chrysotile but not granular one. These chrysotile particles were instilled into mouse trachea. After 4 days, the lung weight had increased almost twice with the fibrous chrysotile bot not garanular chrysotile. The permeability of the lung capillary, which was examined by a modified Evans blue method, varied in proportion to the lung weight, proving that the increase in lung weight is due to augmented permeability of lung capillaries. Also these inflammatory reactions were suppressed by intravenous SOD injection to the mice. These results suggest that the lung edema induced by asbestos inhalation arises due to particle-geometry-dependent superoxide production by macrophages.
収録刊行物
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- 大気環境学会誌
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大気環境学会誌 30 (4), 233-242, 1995
公益社団法人 大気環境学会
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詳細情報 詳細情報について
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- CRID
- 1390282679593907072
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- NII論文ID
- 130004377110
- 10016363812
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- NII書誌ID
- AN10512108
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- ISSN
- 21854335
- 13414178
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可