Inhibition of Helicobacter pylori Urease Activity by Hydroxamic Acid Derivatives.
書誌事項
- 公開日
- 1994
- 資源種別
- journal article
- DOI
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- 10.1248/bpb.17.1329
- 公開者
- 公益社団法人 日本薬学会
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説明
Helicobacter pylori (HP) produces strong urease [EC 3.5.1.5], which is considered to play a role in the pathogenesis of gastritis and peptic ulcers. Inhibitions against this enzyme have been studied with hydroxamic acid (HXA) derivatives of aliphatic or aromatic carboxylic acids, amino acids and dipeptides. A number of HXAs potently inhibited the urease (I50 values were near the order of 10-6M), and H-Ile-Gly-NHOH (I50=0.20×10-6M) was the most potent inhibitor among the derivatives. HP urease was inhibited more potently, in general, than Jack bean (JB) urease by HXAs, and a correlation between the chemical structures of HXA derivatives and their inhibitory effects on HP urease was observed, in comparison with JB urease.
収録刊行物
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- Ｂｉｏｌｏｇｉｃａｌ ＆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｂｕｌｌｅｔｉｎ
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Ｂｉｏｌｏｇｉｃａｌ ＆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｂｕｌｌｅｔｉｎ 17 (10), 1329-1332, 1994
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679599115648
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- NII論文ID
- 110003640424
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- NII書誌ID
- AA10885497
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- COI
- 1:CAS:528:DyaK2MXksVSnurY%3D
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- ISSN
- 13475215
- 09186158
- https://id.crossref.org/issn/09186158
- http://id.crossref.org/issn/09186158
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- PubMed
- 7874052
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- 本文言語コード
- en
-
- 資料種別
- journal article
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可
