Pharmacological Properties of Traditional Medicines.22.Pharmacokinetic Study of Mulberroside A and Its Metabolites in Rat
書誌事項
- タイトル別名
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- Pharmacological Properties of Traditional Medicines. XXII. Pharmacokinetic Study of Mulberroside A and Its Metabolites in Rat.
- Pharmacological Properties of Tradition
- 公開日
- 1996
- 資源種別
- journal article
- DOI
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- 10.1248/bpb.19.1463
- 公開者
- 公益社団法人 日本薬学会
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説明
To identify the active components in Mori Cortex (Chinese medicine), Mori Cortex extracts were administered orally to rats, and then blood plasma, urine, and bile were analyzed. The results showed only a few remaining metabolites of mulberroside A. Consequently, to clarify the transitional properties of mulberroside A derivatives to tissues and the in vivo abundance ratio of mulberroside A compounds, the pharmacokinetics of mulberroside A derivatives were investigated in this study. When Mori Cortex extracts were administered orally, mulberroside A was only detected in small quantities in the plasma, and its bioavailability was a bout 1%. This is due to the first pass effect, by which most mulberroside A was converted into oxyresveratrol and transported into the circulating blood, and its absorption ratio was estimated at about 50%. Oxyresvertrol was also found to be transported to tissues at high rates. As a result, when analyzing the pharmacological activity of the Mori Cortex in vitro, it is more useful to study oxyresveratarol than mulberroside A.
収録刊行物
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- Ｂｉｏｌｏｇｉｃａｌ ＆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｂｕｌｌｅｔｉｎ
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Ｂｉｏｌｏｇｉｃａｌ ＆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｂｕｌｌｅｔｉｎ 19 (11), 1463-1467, 1996
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679599997952
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- NII論文ID
- 110003663348
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- NII書誌ID
- AA10885497
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- COI
- 1:CAS:528:DyaK28Xnt1Oqurc%3D
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- ISSN
- 13475215
- 09186158
- https://id.crossref.org/issn/09186158
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- NDL書誌ID
- 4080089
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- PubMed
- 8951165
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- JaLC
- NDLサーチ
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
