Pharmacological Study on the Novel Antinociceptive Agent, a Novel Monoterpene Alkaloid from Incarvillea sinensis
-
- Chi Yu-Ming
- Seiwa Pharmaceutical, Ltd.
-
- Nakamura Motoyuki
- Seiwa Pharmaceutical, Ltd.
-
- Yoshizawa Toyokichi
- Seiwa Pharmaceutical, Ltd.
-
- Zhao Xi-Ying
- Seiwa Pharmaceutical, Ltd.
-
- Yan Wen-Mei
- Beijing University of Traditional Chinese Medicine and Pharmacy
-
- Hashimoto Fumio
- Faculty of Pharmaceutical Sciences, Kumamoto University
-
- Kinjo Junei
- Faculty of Pharmaceutical Sciences, Kumamoto University
-
- Nohara Toshihiro
- Faculty of Pharmaceutical Sciences, Kumamoto University
この論文をさがす
抄録
To determine the antinociceptive mechanism of incarvillateine (INCA), the opiate antagonists nor-binaltorphimine (nor-BNI), β-funaltrexamine (β-FNA) and naltrindole (NTI) were pretreated prior to its injection in a formalin test. The antinociceptive effect of INCA was antagonized by nor-BNI (κ-receptor antagonist) and β-FNA (μ-receptor antagonist), while NTI (δ-receptor antagonist) did not influence its effect. Furthermore, the antinociceptive effect of INCA was blocked by theophylline (THEO), an adenosine-receptor antagonist. These results suggested that the antinociceptive effect arose from the activation of μ-, κ-receptors and adenosine-receptor.
収録刊行物
-
- Biological & Pharmaceutical Bulletin
-
Biological & Pharmaceutical Bulletin 28 (10), 1989-1991, 2005
公益社団法人 日本薬学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390282679603351936
-
- NII論文ID
- 110003666380
-
- NII書誌ID
- AA10885497
-
- ISSN
- 13475215
- 09186158
-
- NDL書誌ID
- 7453365
-
- PubMed
- 16204962
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可