Antiproliferative Constituents in the Plant 8. Seeds of Rhynchosia volubilis.
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- KINJO Junei
- Faculty of Pharmaceutical Sciences, Fukuoka University
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- NAGAO Tsuneatsu
- Faculty of Pharmaceutical Sciences, Fukuoka University
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- TANAKA Takashi
- School of Pharmaceutical Sciences, Nagasaki University
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- NONAKA Gen-ichiro
- Usaien Pharm. Co., Ltd.
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- OKABE Hikaru
- Faculty of Pharmaceutical Sciences, Fukuoka University
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The MeOH extract of the seeds of Rhynchosia volubilis (Leguminosae) showed antiproliferative activity against human gastric adenocarcinoma [MK-1, 50% growth inhibition (GI50): 25 μg/ml], human uterus carcinoma (HeLa, GI50: 30 μg/ml), and murine melanoma (B16F10, GI50: 8 μg/ml) cells. Bioactivity-guided fractionation resulted in the isolation of gallic acid methylester (1), gallic acid (2), 7-O-galloylcatechin (3), 1,6-di-O-galloylglucose (4), 1-O-galloylglucose (5), and trigalloylgallic acid (6), and their antiproliferative activity was estimated. All showed much stronger inhibition against B16F10 cell growth than against HeLa and MK-1 cell growth. Compound 2 and its tetramer (6) with a free carboxyl group showed higher activity than those which did not have a free carboxyl group. In relation to the gallic acid tetramer (6), two gallic acid dimers (ellagic acid and dehydrodigallic acid) and trimers (tergallic acid dilactone and flavogallonic acid dilactone) were tested for their activity, and compared with those of the isolates.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 24 (12), 1443-1445, 2001
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679603959552
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- NII論文ID
- 110003638439
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- NII書誌ID
- AA10885497
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- COI
- 1:CAS:528:DC%2BD3MXosl2rs7o%3D
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- ISSN
- 13475215
- 09186158
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- HANDLE
- 10069/8375
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- NDL書誌ID
- 5995943
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- PubMed
- 11767121
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可