The Role of Dihydropyrazines in Accelerated Death of Escherichia coli on Addition of Copper(II)
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- Takeda Osamu
- Department of Hygiene, Miyazaki Medical College Department of Public Health, Miyazaki Medical College
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- Takechi Shinji
- Department of Hygiene, Miyazaki Medical College
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- Katoh Takahiko
- Department of Public Health, Miyazaki Medical College
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- Yamaguchi Tadatoshi
- Department of Hygiene, Miyazaki Medical College
書誌事項
- タイトル別名
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- Role of Dihydropyrazines in Accelerated Death of Escherichia coli on Addition of Copper 2
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説明
Dihydropyrazines (DHPs), which are derived from sugars, inhibit the growth of Escherichia coli. Addition of copper(II) ion (Cu2+) accelerates the effect of DHPs, resulting in cell death. Investigation of the lethal effect in several DNA repair-deficient or detoxifying enzyme-deficient mutant strains and radical scavengers suggested that the cytotoxic and genotoxic damage was caused by radical species (hydroxyl, superoxide anion, and carbon-centered radicals) generated from reaction of DHPs with Cu2+.
収録刊行物
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- Ｂｉｏｌｏｇｉｃａｌ ＆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｂｕｌｌｅｔｉｎ
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Ｂｉｏｌｏｇｉｃａｌ ＆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｂｕｌｌｅｔｉｎ 28 (7), 1161-1164, 2005
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679604300544
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- NII論文ID
- 10016664984
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- NII書誌ID
- AA10885497
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- COI
- 1:CAS:528:DC%2BD2MXpsFaiu7w%3D
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 7343320
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- PubMed
- 15997090
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可