Metabolite Profiles of Flutamide in Serum from Patients with Flutamide-Induced Hepatic Dysfunction
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- Takashima Eiji
- Laboratory of Pharmaceutics, Gifu Pharmaceutical University
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- Iguchi Kazuhiro
- Laboratory of Pharmaceutics, Gifu Pharmaceutical University
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- Usui Shigeyuki
- Laboratory of Pharmaceutics, Gifu Pharmaceutical University
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- Yamamoto Hajime
- Toyama Prefectural Central Hospital
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- Hirano Kazuyuki
- Laboratory of Pharmaceutics, Gifu Pharmaceutical University
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Hepatic dysfunction due to flutamide administration has been reported and this side effect often limits the use of the agent. The prediction of flutamide-induced hepatotoxicity is attributed to the proper use of the antiandrogen. In this study, we investigated whether hepatic dysfunction could be assessed by the metabolite profile in serum from patients receiving this drug. Serum samples were obtained from 15 patients with prostate cancer, 12 patients with no sign of hepatotoxicity and 3 patients with slight hepatic dysfunction during long-term flutamide treatment. We analyzed the metabolite profiles by LC/MS in selected ion monitoring mode and detected a new metabolite (M3) that was an oxidation product of flutamide. However, there were no consistent differences in the serum flutamide metabolites between patients with normal function and those suffering hepatic dysfunction. The metabolite profiles in the β-glucuronidase-treated serum showed a similar pattern between normal functioning and dysfunctional groups. Thus, the profile of flutamide metabolites determined in serum may not contribute to the risk prediction of flutamide-related hepatotoxicity.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 26 (10), 1455-1460, 2003
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679604398336
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- NII論文ID
- 110003608324
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 6696595
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- PubMed
- 14519954
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可