Flavone Markedly Affects Phenotypic Expression of β-Lactam Resistance in Methicillin-Resistant <i>Staphylococcus aureus</i> Strains Isolated Clinically
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- Shibata Hirofumi
- Faculty of Pharmaceutical Sciences, The University of Tokushima
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- Shirakata Chikako
- Faculty of Pharmaceutical Sciences, The University of Tokushima
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- Kawasaki Hiromi
- Faculty of Pharmaceutical Sciences, The University of Tokushima
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- Sato Yoichi
- Faculty of Pharmaceutical Sciences, The University of Tokushima
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- Kuwahara Tomomi
- Graduate School of Medicine, The University of Tokushima
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- Ohnishi Yoshinari
- Graduate School of Medicine, The University of Tokushima
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- Arakaki Naokatu
- Faculty of Pharmaceutical Sciences, The University of Tokushima
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- Higuti Tomihiko
- Faculty of Pharmaceutical Sciences, The University of Tokushima
Bibliographic Information
- Other Title
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- Flavone Markedly Affects Phenotypic Expression of β-Lactam Resistance in Methicillin-Resistant Staphylococcus aureus Strains Isolated Clinically
- Flavone Markedly Affects Phenotypic Expression of ベータ Lactam Resistance in Methicillin Resistant Staphylococcus aureus Strains Isolated Clinically
- Flavone Markedly Affects Phenotypic Expression of β-Lactam Resistance in Methicillin-Resistant <i>Staphylococcus aureus</i> Strains Isolated Clinically
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Abstract
Flavone and its derivatives had very weak antibacterial effects on methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive S. aureus, but dramatically intensified MRSA's susceptibility to β-lactams. We named these compounds “ILSMR (intensifier of β-lactam-susceptibility in MRSA).” We also found discrepancies among MRSA strains in their responses to flavone; some strains showed phenotypic susceptibility to methicillin while others showed phenotypic resistance to it. To understand the mechanism underlying this discrepancy, we characterized 20 MRSA strains in detail, analyzed their conventional and molecular typings, and examined each strain's resistance to β-lactams, with COL serving as a reference. Neither SCCmec typing nor coagulase typing explained the diverse effects of flavone on the β-lactam MICs of these strains. Likewise, changes in pulsed-field gel electrophoresis (PFGE) type were not associated with the profiles of ILSMR effects. However, the present observations suggest that the ILSMR effects on MRSA is strain-specific, and that this effect depends on an as-yet unknown mechanism that is essential for the expression of the phenotype conferring β-lactam resistance to MRSA strains, independently of an interaction with the mecA-encoded penicillin-binding protein 2a or with the β-lactamase.
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 26 (10), 1478-1483, 2003
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282679604409856
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- NII Article ID
- 110003608328
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- NII Book ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL BIB ID
- 6696665
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- PubMed
- 14519958
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed