Involvement of Histaminergic System in the Anxiolytic-Like Activities of Morus alba Leaves in Mice

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  • Lee Seungheon
    Department of Aquatic Biomedical Sciences, School of Marine Biomedical Sciences, College of Ocean Science, Jeju National University
  • Kim Dong Hyun
    School of Clinical Sciences, University of Bristol
  • Lee Ji Hye
    Department of Herbal Medicinal Pharmacology, College of Herbal Bio-industry, Daegu Haany University
  • Ko Eun Seong
    Department of Aquatic Biomedical Sciences, School of Marine Biomedical Sciences, College of Ocean Science, Jeju National University
  • Oh Won Bo
    Department of Aquatic Biomedical Sciences, School of Marine Biomedical Sciences, College of Ocean Science, Jeju National University
  • Seo Yong Taek
    Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University
  • Jang Young Pyo
    Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University Kyung Hee East-West Pharmaceutical Research Institute, College of Pharmacy, Kyung Hee University
  • Ryu Jong Hoon
    Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University Kyung Hee East-West Pharmaceutical Research Institute, College of Pharmacy, Kyung Hee University
  • Jung Ji Wook
    Department of Herbal Medicinal Pharmacology, College of Herbal Bio-industry, Daegu Haany University

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  • Involvement of Histaminergic System in the Anxiolytic-Like Activities of <i>Morus alba</i> Leaves in Mice

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The aim of this study was to identify the effects of 85% methanolic extract of Morus alba leaves (EMA), which is a traditional herb, in mice. The effects of EMA on the anxiolytic-like behaviour were studied using the elevated plus maze (EPM) and hole-board test. To elucidate the mode of action of the anxiolytic-like effects of EMA, the mice were subjected to the co-administration of EMA (200 mg/kg, per os (p.o.)) and either antagonist. EMA (at 200 or 400 mg/kg) significantly increased the percentages of time-spent in the open arms and entries into the open arms of the EPM versus vehicle-treated control group (p<0.05). Moreover, in the hole-board test, EMA (200 and 400 mg/kg) significantly increased the number of head-dips versus vehicle-treated control group (p<0.05). However, there were no changes in the locomotor activity and myorelaxant effects in any group compared with the vehicle-treated control group. In addition, the anxiolytic-like effects of EMA were abolished by thioperamide (10 mg/kg, intraperitoneally (i.p.)), which is a histamine H3 receptor antagonist. Moreover, results from reverse transcription polymerase chain reaction (RT-PCR) also revealed that the amygdalal histidine decarboxylase mRNA expression levels in EMA (200 mg/kg)-treated group were significantly higher than those in the vehicle-treated controls (p<0.05). These results suggest that EMA might prove to be an effective anxiolytic agent and that EMA acts via the histaminergic system in central nerve system.

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