書誌事項
- タイトル別名
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- Interaction between endothelin-1 and noradrenalin in human stroke.
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抄録
Endothelin-1 (ET-1) is a recently identified 21-amino acid peptide produced by the vascular endothelium and is the most potent known vasoconstrictor. The present study attempted to evaluate the interaction between the level of ET-1 and the concentration of noradrenalin in the plasma over a period of 2 weeks following an episode of cerebral hemorrhage. Thirty-seven patients with cerebral hemorrhage were examined. We estimated the immunoreactive ET-1 by radioimmunoassay. The level of ET-1 during the acute stage (day 7) was 4.03 ± 1.32 pg/ml, which was significantly higher than that (2.03± 1.38 pg/ml) during the subacute stage (day 8 to day 14). During the acute stage, a close relationship existed between the ET-1 (X) and noradrenalin (Y). Linear regression analysis yielded the following equation : Y= 148.62X -18.38 (r = 0.555, p <0.01). Also, during the subacute stage, the increase in level of ET-1 (X) with noradrenalin (Y) revealed an excellent linear relationship (Y=251.1X + 196.08; r = 0.867, p<0.01). These linear regressions obtained during the acute stage and during the subacute stage displayed a significant difference (p < 0.01). In conclusion, the time course of interaction between ET-1 and noradrenalin may be closely related to the functional sequence of derangement of both the endothelium and noradrenalin nervous system.
収録刊行物
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- 脳卒中
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脳卒中 18 (1), 25-30, 1996
一般社団法人 日本脳卒中学会
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詳細情報 詳細情報について
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- CRID
- 1390282679616037120
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- NII論文ID
- 130003631201
- 10009278253
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- NII書誌ID
- AN0020186X
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- ISSN
- 18831923
- 09120726
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可