The Relationship between Brain Activation When Anticipating Emotional Stimulus in Uncertain Situations and Harm Avoidance: An fMRI Study

DOI Web Site Web Site 22 References
  • MAKITA Kai
    Graduate School of Biomedical & Health Sciences, Hiroshima University
  • KANAYAMA Noriaki
    Graduate School of Biomedical & Health Sciences, Hiroshima University
  • UYAMA Takuto
    School of Medicine, Hiroshima University
  • MACHIZAWA Maro
    Graduate School of Biomedical & Health Sciences, Hiroshima University
  • SASAOKA Takafumi
    Graduate School of Biomedical & Health Sciences, Hiroshima University
  • YAMAWAKI Shigeto
    Graduate School of Biomedical & Health Sciences, Hiroshima University

Bibliographic Information

Other Title
  • 不確実な感情惹起イベント予期時における脳活動と損害回避得点の関連性――fMRIを用いた検討――
  • フカクジツ ナ カンジョウ ジャッキ イベント ヨキジ ニ オケル ノウ カツドウ ト ソンガイ カイヒ トクテン ノ カンレンセイ : fMRI オ モチイタ ケントウ

Search this article

Abstract

<p>Psychological and neuroimaging studies have revealed a close relation between adaptive behaviors and psychiatric disorders as well as functional responses to exposed emotional events. Nevertheless, relation between a trait of harm avoidance and neural reactions to ‘uncertain’ events is not well studied. Here, we used functional magnetic resonance imaging (fMRI) to examine whether the trait of harm avoidance, as measured by Temperament and Character Inventory (TCI), relates to functional activations in anticipation of ‘uncertain’ emotional events compared to when upcoming emotional event was ‘certain.’ Healthy young adult participants (N=17) were exposed to emotional, valence-inducing images preceded by ‘certain’ or ‘uncertain’ auditory cues. Compared with emotional ‘certain’ conditions, harm avoidance score was positively correlated with brain activation in the bilateral insula and the mid-cingulate cortex while no correlations were found for decreased activation. Individuals with high harm avoidance showed excessive activations in these regions. Our results may provide an additional evidence for the possible relations among adaptive behavior, excessive neural responses to uncertain events (taken as negative), and vulnerability to depression and/or anxiety.</p>

Journal

References(22)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top