Determination of aluminum acetylsalicylate in pharmaceutical preparations

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Other Title
  • 混合製剤中のアセチルサリチル酸アルミニウムの定量
  • コンゴウ セイザイ チュウ ノ アセチル サリチルサン アルミニゥム ノ テイリョウ
  • Analytical studies on drugs by infrared absorption spectroscopy. II
  • 赤外線吸収スペクトルによる医薬品の分析的研究 (第2報)

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Description

Aluminum acetylsalicylate (I) was treated with NH4F·HF and triethanolamine to be converted to triethanolamine acetylsalicylate, and was determined by infrared absorption spectroscopy taking an absorption at 1750 cm-1 as the key band.<BR>The recommended procedure was as follows. Take the sample containing 25 mg of (I) in a 20 ml glass-stoppered test tube. Add 10 ml of 5% triethanolamine-chloroform solution and 50 mg of NH4F·HF, and shake for about 30 min. Filter through a glass filter and measure the absorbance of the filtrate at 1750 cm-1 (E<SIB>T) against 5% triethanolamine-chloroform solution. At the same time measure the absorbance of standard solution (ES), and calculate the amount of (I) from E<SIB>T/ES.

Journal

  • BUNSEKI KAGAKU

    BUNSEKI KAGAKU 17 (6), 708-713, 1968

    The Japan Society for Analytical Chemistry

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