混合製剤中のアセチルサリチル酸アルミニウムの定量

立沢 政義, 下田 通敏

doi:10.2116/bunsekikagaku.17.708

混合製剤中のアセチルサリチル酸アルミニウムの定量

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立沢政義

国立衛生試験所医薬品部
下田通敏

昭和薬品化工株式会社開発研究部

書誌事項

タイトル別名

Determination of aluminum acetylsalicylate in pharmaceutical preparations
コンゴウセイザイチュウノアセチルサリチルサンアルミニゥムノテイリョウ
Analytical studies on drugs by infrared absorption spectroscopy. II
赤外線吸収スペクトルによる医薬品の分析的研究 (第2報)

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説明

Aluminum acetylsalicylate (I) was treated with NH₄F·HF and triethanolamine to be converted to triethanolamine acetylsalicylate, and was determined by infrared absorption spectroscopy taking an absorption at 1750 cm^-1 as the key band.<BR>The recommended procedure was as follows. Take the sample containing 25 mg of (I) in a 20 ml glass-stoppered test tube. Add 10 ml of 5% triethanolamine-chloroform solution and 50 mg of NH₄F·HF, and shake for about 30 min. Filter through a glass filter and measure the absorbance of the filtrate at 1750 cm^-1 (E<SIB>_T) against 5% triethanolamine-chloroform solution. At the same time measure the absorbance of standard solution (E_S), and calculate the amount of (I) from E<SIB>_T/E_S.