トルエン，キシレン，エチルベンゼンの尿中代謝物６種の同時測定法とグラビア印刷作業者での生物学的モニタリング

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タイトル別名
  • Method for simultaneous determination of six metabolites of toluene, xylene and ethylbenzene, and its application to exposure monitoring of workers in a printing factory with gravure machines.
  • トルエン キシレン エチルベンゼン ノ ニョウチュウ タイシャブツ 6シュ ノ

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説明

For the biological monitoring of exposure to solvent composed of toluene, xylene, and ethylbenzene used in a printing factory with gravure machines, we developed a HPLC method for the simultaneous determination of urinary metabolites of this solvent, i.e. hippuric acid, o-, m-, and p- methylhippuric acid, mandelic acid and phenylglyoxylic acid. Except for phenylglyoxylic acid, urinary concentrations of the metabolites determined by the present method correlated well with the air concentrations of the respective solvent components. Hence the present method is useful in monitoring solvent exposure. In 91 workers of the printing factory and 53 control subjects, we also determined the concentrations of some phenolic metabolites and confirmed that o-cresol is a useful indicator for monitoring toluene exposure.

収録刊行物

  • 産業医学

    産業医学 31 (1), 9-16, 1989

    社団法人 日本産業衛生学会

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