書誌事項
- タイトル別名
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- Pharmacokinetic studies of terguride (2): Absorption and excretion in rabbits.
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説明
The absorption and excretion of terguride in rabbits were studied.<BR> 1. After oral administration of 14C-terguride (1 mg/kg) to female rabbits, the radioactivity in plasma reached the maximum (Cmax) at 1hr and disap peared with a half-life of 1.9hr. Concentration of terguride in plasma reached Cmax at 0.25 ?? 1 hr and disappeared with a half-life of 1.2hr. Similar plasma kinetics was observed in male rabbits. Urinary and fecal excretion within 7days after oral dosing was 41 and 53%, respectively.<BR> 2. The bioavailability of terguride after oral administration was about 39%<BR> 3. Food intake before oral administration of unlabelled terguride (0.2mg/animal) decreased (about 30%) the Cmax, whereas the increase was induced by neutralization of stomach pH, however, no effect of their treatment on Tmax and availability was found.
収録刊行物
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- 薬物動態
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薬物動態 8 (5), 1011-1016, 1993
日本薬物動態学会
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詳細情報 詳細情報について
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- CRID
- 1390282679644531840
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- NII論文ID
- 130003561583
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- ISSN
- 09161139
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
