Cisplatin and Pemetrexed Chemotherapy After Systemic Chemotherapy in a Patient with Malignant Pleural Mesothelioma

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  • 悪性胸膜中皮腫に対して２次化学療法としてＣｉｓｐｌａｔｉｎ＋Ｐｅｍｅｔｒｅｘｅｄが有効であった１例

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Background. Malignant pleural mesothelioma (MPM) is associated with a poor prognosis and is often resistant to treatment. Cisplatin+pemetrexed (CP) is a standard regimen for the first-line treatment of MPM. Unfortunately, no data are available on the efficacy of this chemotherapy regimen in patients who have received previous systemic chemotherapy. Case. A 73-year-old man was admitted because of pleural effusion in February 2006, and a mediastinal lymph node biopsy confirmed a diagnosis of malignant mesothelioma. Chemotherapy with cisplatin and gemcitabine, followed by radiotherapy, was then performed. As continuous effects were not obtained, second-line chemotherapy with CP was performed. After 4 cycles of CP, stable disease was observed. The only severe toxicity that occurred was thrombocytopenia (Grade 3). He has been followed up closely as an outpatient without chemotherapy for 10 months. Conclusion. This case suggests that patients with MPM may benefit from CP chemotherapy, which has an acceptable toxicity, even after undergoing systemic chemotherapy.<br>

Journal

  • Haigan

    Haigan 48 (3), 227-230, 2008

    The Japan Lung Cancer Society

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