A Case of NUT Midline Carcinoma of the Lung

Kato Ryo, Oikawa Taku, Mizuno Shiro, Osanai Kazuhiro, Toga Hirohisa, Minato Hiroshi

doi:10.2482/haigan.55.1080

Bibliographic Information

Other Title

肺原発NUT midline carcinomaの1例

Description

Background. Nuclear protein of the testis (NUT) midline carcinoma (NMC) is a malignant epithelial tumor that is defined by the rearrangement of the NUT gene on chromosome 15q14. Tumors with NUT gene rearrangement have recently been recognized as NMC. The name is based on their location: they occur on the physical midline organs. The therapeutic approaches for NMC have not yet been established due to the rarity of the disease, and the tumor is known to be associated with a poor prognosis. Case. A 32-year-old man was admitted to our hospital with dyspnea and in a state of shock due to the presence of a huge mass and pleural effusion in the left lung. A thoracoscopic biopsy of the pleura led to a diagnosis of NMC with translocation of the t(15;19) gene and the BRD4-NUT fusion gene. The tumor rapidly increased in size, despite the provision of a combination chemotherapy regimen that consisted of carboplatin and paclitaxel. The patient died due to NMC, two months after the diagnosis. Conclusion. We experienced a case of NMC of the lung that was resistant to combination chemotherapy. NMC should be considered in cases that show anaplastic carcinoma when an immunohistochemical analysis reveals poorly defined characteristics.

Journal

Haigan

Haigan 55 (7), 1080-1085, 2015

The Japan Lung Cancer Society

Keywords

Details 詳細情報について

CRID: 1390282679660199552

NII Article ID: 130005125732

DOI: 10.2482/haigan.55.1080

ISSN: 13489992; 03869628

Web Site: https://www.jstage.jst.go.jp/article/haigan/55/7/55_1080/_pdf; https://search.jamas.or.jp/link/ui/2016209042

Text Lang: ja

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CiNii Articles
OpenAIRE

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