小児・若年者における動脈硬化

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書誌事項

タイトル別名
  • Arteriosclerosis in Children and Young Adults
  • ―冠動脈と大動脈の比較―
  • -Comparative Study on Coronary Arteries and Aortae-

抄録

It has been widely recognized that arteriosclerosis is a silent disease for a long period of time during its progressive stage. Therefore, it seems reasonable to think very important for early stage of it to be investigated in children and young adults.<br>This study was aimed to make the differences clear between coronary arteries and aortae for the purpose of elucidation of local factor (s) of progression of sclerosis.<br>Arteriosclerotic index was caliculated by the method of point counting and Gore's score given to severity of arteriosclerosis, was significantly higher in the aortae (398 cases) than in the coronary arteries (314 cases). In contrast, microscopically proven intimal thickening had significant tendencies that coronary arteries (126 cases) was stronger than aortae (233 cases). Coronary arteries has characteristics of fibrocellular proliferation and weaker lipid deposition in thickened intima, while aortae was characterized by significant lipid deposition in thinner intima. Vasa vasorum became more prominent microscopically in coronary arteries, as intimal thickening progressed, but they did not so in aortae. Circulatory disturbances within the wall might be one of local factors as to coronary arteries.

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