多変量解析を用いた乳腺細胞所見の評価

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  • The evaluation of cytologic findings of breast disease using multivariate statistical analysis.

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We quantied 17 cytologic findings in aspiration cytology specimens in order to determine the diagnostic value of each finding.<BR>In 101 cases of breast disease (50 carcinomas and 51 benign diseases), the degree of the respective cytologic findings was quantified by the appropriate scales. Then, the category score and the coefficient value of each cytologic finding were calculated by using multivariate statistical analysis.<BR>The following cytologic findings showed high coefficient values; distribution of chromatin, nuclear shape, chromatin pattern, naked bipolar nuclei, intercellular connection, and paired cells. These were considered to be important in the diagnosis of breast diseases. The distribution of “total category score” was quite different in malignant and benign cases. In addition, the usefulness of this category score was proved by an external check, which was performed on 20 additional cases.

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