The Role of Apaf-1 in Programmed Cell Death: From Worm to Tumor.
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- Yoshida Hiroshi
- Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University
書誌事項
- タイトル別名
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- Role of Apaf 1 in Programmed Cell Death From Worm to Tumor
- 公開日
- 2003
- 資源種別
- journal article
- DOI
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- 10.1247/csf.28.3
- 公開者
- 日本細胞生物学会
この論文をさがす
説明
Apoptosis or programmed cell death is an important process to eliminate unnecessary or hazardous cells. Apaf-1, a mammalian homologue of CED-4 of C. elegans, is the essential adaptor molecule in the mitochondrial pathway of apoptosis. Mice lacking Apaf-1 show accumulation of neurons in the developing central nervous system due to reduced apoptosis. Apaf-1-deficient cells are remarkably resistant to various apoptotic stimuli. Apaf-1-mediated apoptosis plays a role in the prevention of tumorigenesis. However, Apaf-1-independent cell death pathways are also indicated. In this review, we will summarize what has been learned about the role of Apaf-1 by biochemical and genetical approaches.<br>
収録刊行物
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- Cell Structure and Function
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Cell Structure and Function 28 (1), 3-9, 2003
日本細胞生物学会
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詳細情報 詳細情報について
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- CRID
- 1390282679673200384
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- NII論文ID
- 130004053827
- 50000775056
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- NII書誌ID
- AA0060007X
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- DOI
- 10.1247/csf.28.3
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- COI
- 1:CAS:528:DC%2BD3sXjtVymsL8%3D
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- ISSN
- 13473700
- 03867196
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- NDL書誌ID
- 6487134
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- PubMed
- 12655145
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- JaLC
- NDLサーチ
- Crossref
- PubMed
- CiNii Articles
- OpenAIRE
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- 抄録ライセンスフラグ
- 使用不可
