Retinol Esterification Activity Contributes to Retinol Transport in Stellate Cells.
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- Matsuura Tomokazu
- Department of Internal Medicine I, Jikei University School of Medicine, Minato-ku, Tokyo 105-8461, Japan
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- Nagamori Kazuhiro
- Department of Internal Medicine I, Jikei University School of Medicine, Minato-ku, Tokyo 105-8461, Japan Division of Clinical Pathology, Tohoku Welfare Pension Hospital, Miyagino-ku, Sendai 983-8512, Japan
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- Hasumura Satoshi
- Department of Internal Medicine I, Jikei University School of Medicine, Minato-ku, Tokyo 105-8461, Japan
書誌事項
- 公開日
- 1999
- 資源種別
- journal article
- DOI
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- 10.1247/csf.24.111
- 公開者
- 日本細胞生物学会
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説明
The mechanisms of retinol transport and Accumulation in hepatic stellate cells (HSC) remain to be clucidated. Our previous studies suggested that retinol esterfication activity, particularly lecithin: retinol acyltransferase (LRAT) activity, in liver retinoid metabolism is important to elucidate the relationship between retinol uptake by HSC and the esterification of retinol. In the present study, using a human HSC-like cell line, LI90, we demonstrated that retinol esterification activity of LI90, we demonstrated that retinol esterification activity of LI90 cells is similar to that of primary cultures of rat HSC and higher than that of a human hepatoma cell line. Further, since progesterone or diphos-pho-lauroyl-phosphatidylcholine increased retinol esterification activity of LI90 cells, it is likely that LRAT contributes to retinol esterification in LI90. We examined retinol esterification in LI90 cells and clearance of retinol from culture medium. The percentages of both retinol and esterified retinol in LI90 cells increased in a manner dependent of retinol concentration in medium, whereas that of retinol in medium decreased. The percentages of esterified and unesterified retinol in LI90 cells and of retinol in medium were linearly dependent on the logarithm of the initial concentration of retinol in the medium. These results suggest that retinol esterification activity contributes to retinol uptake by HSC and maintenance of non-toxic retinol levels in plasma.
収録刊行物
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- Cell Structure and Function
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Cell Structure and Function 24 (3), 111-116, 1999
日本細胞生物学会
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詳細情報 詳細情報について
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- CRID
- 1390282679673259648
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- NII論文ID
- 130004137293
- 10002420910
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- NII書誌ID
- AA0060007X
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- COI
- 1:CAS:528:DyaK1MXlsFKhu7g%3D
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- ISSN
- 13473700
- 03867196
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- NDL書誌ID
- 4821027
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- PubMed
- 10462172
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- JaLC
- NDLサーチ
- Crossref
- PubMed
- CiNii Articles
- OpenAIRE
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- 抄録ライセンスフラグ
- 使用不可
