Urinary Aminoacetophenone Derivatives and Their Biosynthesis

DOI
  • KASEDA Hiroki
    Division of Clinical Biochemistry, Research Institute for Medical Science, Wakayama Medical College
  • NOGUCHI Tomoo
    Division of Clinical Biochemistry, Research Institute for Medical Science, Wakayama Medical College
  • KIDO Ryo
    Division of Clinical Biochemistry, Research Institute for Medical Science, Wakayama Medical College

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  • 26尿中アミノアセトフェノン関連物質について

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Studies were carried out on the urinary excretion and biosynthetic pathways of aminoacetophenone derivatives.<BR>1. Administration of tryptophan to hens or rats resulted in occurrence of aminoacetophenone (AAP), 2-amino-3-hydroxyacetophenone (3 HAAP) and 2-amino- 5-hydroxyacetophenone (5 HAAP).<BR>2. Kynurenine was enzymically converted to kynurenamine by 0.01 M phosphate buffer (pH 8. 0) extract of rat liver and then non enzymically to AAP.<BR>3. 5HAAP was formed from 5-hydroxykynurenine via 5-hydroxykynurenamine by 0.01 M phosphate buffer (pH 8. 0) extract of rat small intestine through the similar route to that of formation of AAP from kynurenine.<BR>4. Rat liver rnicrosomes catalyzed hydroxylation of AAP to yield 3HAAP in the presence of NADPH.

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