Effect of Pre-emptive Analgesia with Morphine, Butorphanol, or Buprenorphine on Inhalation Anesthesia and Post-operative Pain Control in Dogs

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  • YAMASHITA Kazuto
    Department of Veterinary Surgery I, School of Veterinary Medicine, Rakuno Gakuen University
  • ANDOH Mari
    Department of Veterinary Surgery I, School of Veterinary Medicine, Rakuno Gakuen University
  • NAKATSU Takuya
    Department of Veterinary Surgery I, School of Veterinary Medicine, Rakuno Gakuen University
  • MATSUMOTO Noriko
    Department of Veterinary Surgery I, School of Veterinary Medicine, Rakuno Gakuen University
  • MAFUNE Naoto
    Department of Veterinary Surgery I, School of Veterinary Medicine, Rakuno Gakuen University
  • KUSHIRO Tokiko
    Department of Veterinary Surgery I, School of Veterinary Medicine, Rakuno Gakuen University
  • UMAR Mohammed Ahmed
    Department of Veterinary Surgery I, School of Veterinary Medicine, Rakuno Gakuen University
  • TSUZUKI Keiko
    Department of Veterinary Surgery I, School of Veterinary Medicine, Rakuno Gakuen University
  • MAEHARA Seiya
    Department of Veterinary Surgery I, School of Veterinary Medicine, Rakuno Gakuen University
  • SENO Takahiro
    Department of Veterinary Surgery I, School of Veterinary Medicine, Rakuno Gakuen University
  • IZUMISAWA Yasuharu
    Department of Veterinary Surgery I, School of Veterinary Medicine, Rakuno Gakuen University

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Other Title
  • 犬の吸入麻酔および術後とう痛管理におけるモルヒネ，ブトルファノール，またはブプレノルフィンを用いた先取り鎮痛の効果
  • 犬の吸入麻酔および術後疼痛管理におけるモルヒネ,ブトルファノール,またはブプレノルフィンを用いた先取り鎮痛の効果
  • イヌ ノ キュウニュウ マスイ オヨビ ジュツゴ トウツウ カンリ ニ オケル モルヒネ ブトルファノール マタワ ブプレノルフィン オ モチイタ サキドリ チンツウ ノ コウカ

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Anesthetic and analgesic effects of pre-emptive analgesia with morphine, butorphanol, or buprenorphine were evaluated in 160 dogs. All dogs were premedicated by an intravenous injection (IV) of acepromazine 0.005 mg/kg with an intramuscular injection (IM) of morphine 0.3 mg/kg (group ACP-MOR, n=40), butorphanol 0.3 mg/kg (group ACP-BTR, n=40), or buprenorphine 0.02 mg/kg (group ACP-BUP, n=40), or without opioid (group ACP, n=40). All dogs were anesthetized by ketamine 5.0 mg/kg IV followed by intratracheal intubation. Surgical anesthesia was maintained by inhalation anesthesia with 50% nitrous oxide-50% oxygen-sevoflurane. All dogs received ketoprofen 1.0 mg/kg IM and buprenorphine 0.01 mg/kg IM after surgery as post-operative pain treatment. The end-expiratory concentration of sevofluranc during surgery was significantly reduced by the opioid combination (1.9∼2.2% in group ACP vs 1.7∼1.9% in groups ACP-MOR, ACP-BTR and ACP-BUP ; p<0.01). Opioid combination had a minimum side effect on cardiopulmonary function in dogs during anesthesia. Post-operative pain was acceptable level in all dogs. Dogs of group ACP-MOR showed more comfortable attitude in postoperative period than those of group ACP (p<0.05).

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