RETROSPECTIVE ANALYSIS OF EFFECT OF ADJUNCTIVE CHEMOTHERAPY TO PREVENT DISTANT METASTASES IN PATIENTS WITH NASOPHARYNGEAL CANCER TREATED WITH RADIOTHERAPY

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  • 上咽頭癌に対する放射線治療例における補助化学療法に関する検討

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A multi-institutional questionnaire regarding chemotherapy procedures in patients with nasopharyngeal carcinoma receiving radiotherapy was conducted. Three-hundred and eighty-five patients were accumulated and 360 patients were the subjects for survival analysis. More than 80% of patients with stage II-IV disease received chemotherapy. Keratinizing histology was an independent prognostic factor indicating worse prognosis, and locoregional controls were significantly worse in these patients compared to those with non-keratinizing histology. Five-year overall survival rates in patients with stage I, II, III, and IV disease were 89%, 83%, 61%, and 48%, respectively in patients with non-keratinizing disease, whereas the rate was 49% in those with keratinizing disease. Concurrent, cisplatin-based chemotherapy achieved a significantly better relapse-free rate in patients with stage VI, non-keratinizing disease.

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